Target and Biomarker Validation

The Asterand Bioscience team delivers high quality molecular pathology and genomics data to support the selection and validation of drug targets and biomarkers in human tissues.  In addition, the approaches we provide are ideally suited for diagnostic assay development and testing. Our molecular pathology and qRT-PCR platforms are used to great effect as endpoints for our human primary cell based assays. This allows changes in the expression of key targets to be determined following treatment of human cells with novel therapeutic agents.

Gene Expression

Asterand Bioscience utilizes multiple techniques in order to determine gene expression and localization, including branched chain in situ hybridization, fluorescence in situ hybridization, quantitative PCR and qRT-PCR. With over 20 years’ experience of expression profiling in human tissues using these techniques, our platforms provide robust, gene expression data in diseased and non-diseased human tissues. These data are used to support target selection, to understand tissue specific, disease relevant or population differences in gene expression, to alert investigators to potential safety liabilities and to validate animal models.

Protein Expression

The Asterand Bioscience team delivers high quality molecular pathology data to support the selection and validation of drug targets and biomarkers in human tissues.  In addition, the approaches we provide are ideally suited for diagnostic assay development and testing. Our molecular pathology platforms are used to great effect as endpoints for our human primary cell based assays. This allows changes in the expression of key targets to be determined following treatment of human cells with novel therapeutic agents.

 

For more information, or to discuss a specific study, please contact us at advantage@asterandbio.com.