Asterand offers a unique capability based on the combined analysis of quantitative gene expression and protein expression. XpressArray™ is our platform for immunohistochemistry that utilizes a series of human tissue microarrays constructed in-house, the content of which match the human tissues in our XpressWay™ Proﬁles. 72 different human tissues, each from 3 non-diseased donors, are represented in our XpressArray™ platform. These arrays can be examined immunohistochemically to determine the precise location of the proteins of interest based on the quantitative gene expression data from an XpressWay™ Proﬁle for your target.
The data shown illustrate the value of a combined qRT-PCR and immunohistochemical approach. Where target copy numbers are low, protein expression might be predicted to be equally low. But in DRG, prostanoid EP4-receptor immunoreactivity was found to be located speciﬁcally within the ganglion cells, suggesting a role for EP4-receptors in the modulation of sensory information, including pain. These observations, derived from the use of XpressArray™, add signiﬁcantly to the value of the data generated within XpressWay™ Proﬁles.